heparan sulfate glucosamine 3-O-sulfotransferase 4; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4; 3-OST-4; heparan sulfate 3-O-sulfotransferase 4; h3-OST-4 (HS3ST4, 3OST4)

Function

• transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
• unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (putative)

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (probable)

Expression

brain-specific

More general terms

• heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)
• membrane protein

Additional terms

• glucosamine (Cosamin, Osteo-Bi-Flex)
• heparan sulfate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9951
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9951
• OMIM: https://mirror.omim.org/entry/604059
• UniProt: http://www.uniprot.org/uniprot/Q9Y661.html