heparan sulfate glucosamine 3-O-sulfotransferase 2 (heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, heparan sulfate 3-O-sulfotransferase 2, h3-OST-2, UNQ2442/PRO5004 HS3ST2, 3OST2)

Function

• transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
• catalyzes O-sulfation of glucosamine in GlcA2S-GlcNS
• unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

• Golgi apparatus membrane
• single-pass type 2 membrane protein (probable)

Expression

• highly expressed in brain
• weakly expressed in the heart, placenta, lung & skeletal muscle

More general terms

• heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)
• membrane protein

Additional terms

• glucosamine (Cosamin, Osteo-Bi-Flex)
• heparan sulfate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9956
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9956
• OMIM: https://mirror.omim.org/entry/604056
• UniProt: http://www.uniprot.org/uniprot/Q9Y278.html