sialic acid-binding Ig-like lectin 6; siglec-6; Obesity-binding protein 1; OB-BP1; CD33 antigen-like 1; CDw327; CD327 (SIGLEC6, CD33L, CD33L1, OBBP1)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• binds to alpha-2,6-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
• interacts with LEP

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoform 1: cell membrane; single-pass type 1 membrane protein
• isoform 2: secreted

Alternative splicing

named isoforms=4

Expression

• expressed at high levels in placenta
  • cytotrophoblastic cells
  • syncytiotrophoblastic cells
• expressed at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) & small intestine

Notes

• should not be confused with SIGLEC5 which has been called CD33L2

More general terms

• sialic acid-binding immunoglobulin-like lectin
• CD antigen

Additional terms

• sialic acid-binding Ig-like lectin 5; siglec-5; obesity-binding protein 2; OB-binding protein 2; OB-BP2; CD33 antigen-like 2; CD170 (SIGLEC5, CD33L2, OBBP2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=946
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:946
• OMIM: https://mirror.omim.org/entry/604405
• UniProt: http://www.uniprot.org/uniprot/O43699.html