sialic acid-binding Ig-like lectin 5; siglec-5; obesity-binding protein 2; OB-binding protein 2; OB-BP2; CD33 antigen-like 2; CD170 (SIGLEC5, CD33L2, OBBP2)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• binds equally to alpha-2,3-linked & alpha-2,6-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• monocytic/myeloid lineage cells
  • peripheral blood leukocytes - monocytes, neutrophils
  • spleen
  • bone marrow
• lymph node, lung, appendix, placenta, pancreas & thymus - lower levels
• not expressed in leukemic cell lines representing early stages of myelomonocytic differentiation

More general terms

• CD antigen
• sialic acid-binding immunoglobulin-like lectin
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8778
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8778
• OMIM: https://mirror.omim.org/entry/604200
• UniProt: http://www.uniprot.org/uniprot/O15389.html