testis-expressed protein 101 (scleroderma-associated autoantigen, cell surface receptor NYD-SP8, spermatogenesis-related gene protein, TEX101, SGRG, UNQ867/PRO1884)

Function

• role in signal transduction
• promote protein tyrosine phosphorylation (putative)
• interacts with VAMP3

Structure

• N-glycosylated
• contains 1 UPAR/Ly6 domain

Compartment

cell membrane, GPI-anchor

Alternative splicing

named isoforms=2

Expression

• detected in testis & spermatogonia
• not detected in spermatocytes
• detected in blood leukocytes

Pathology

• antibodies against TEX101 are present in sera from patients with scleroderma

More general terms

• glypiated protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BY14.html