lymphocyte antigen Ly-6E (retinoic acid-induced gene E protein, RIG-E, thymic shared antigen 1, TSA-1, stem cell antigen 2, SCA-2)

Function

• activated by IFN-alpha in monocytic cell line U-937 & in peripheral blood monocyte cells

Structure

• contains 1 UPAR/Ly6 domain

Compartment

cell membrane, GPI-anchor

Expression

• widely expressed, predominantly in liver, kidney, ovary, spleen, peripheral blood Leukocytes

Pathology

• induced by retinoic acid in promyelocytic leukemia NB4 & in myeloblast HL-60 cell lines

More general terms

• glypiated protein

Database

• OMIM: https://mirror.omim.org/entry/601384
• UniProt: http://www.uniprot.org/uniprot/Q16553.html