reversion-inducing cysteine-rich protein with Kazal motifs (hRECK, suppressor of tumorigenicity 15, ST15, RECK)

Function

• negatively regulates matrix metalloproteinase-9 (MMP9)
  • suppresses MMP9 secretion
  • inhibits enzymatic activity on MMP9
• regulates MMP-2 & MT1-MMP (putative)

Structure

• N-glycosylated, GPI anchor
• contains 3 Kazal-like domains

Compartment

cell membrane, GPI-anchor

Expression

expressed in various tissues & untransformed cells

Pathology

• down-regulation of RECK by oncogenic signals may facilitate tumor invasion & metastasis
• detectable in tumor-derived cell lines & oncogenically transformed cells

More general terms

• glypiated protein

Database

• OMIM: https://mirror.omim.org/entry/605227
• UniProt: http://www.uniprot.org/uniprot/O95980.html