CD177 (polycythemia rubra vera protein 1, PRV-1, NB1 glycoprotein, NB1 GP, human neutrophil alloantigen 2a, HNA-2a, NB1, PRV1, UNQ595/PRO1181)

Structure

N-glycosylated

Compartment

• cell membrane, GPI-anchor
• a soluble form may also be produced by proteolytic cleavage at the cell surface (shedding)

Alternative splicing

named isoforms=3

Expression

• highly expressed in normal bone marrow
• weakly expressed in fetal liver
• induction by CSF3 in resting granulocytes

Pathology

• expressed on neutrophils, granulocytes of patients with polycythemia vera (PV) & with essential thrombocythemia (ET)
• induced in patients with polycythemia vera (PV) & with essential thrombocythemia

More general terms

• glypiated protein

Additional terms

• polycythemia rubra vera (PRV, PV, erythremia)

Database

• OMIM: https://mirror.omim.org/entry/162860
• UniProt: http://www.uniprot.org/uniprot/Q8N6Q3.html