hyaluronidase PH-20; hyal-PH20; hyaluronoglucosaminidase PH-20; sperm adhesion molecule 1; sperm surface protein PH-20 (SPAM1 HYAL3 PH20)

Function

• sperm-egg adhesion
• penetration of the layer of cumulus cells surrounding the egg & zona pellucid by digesting hyaluronic acid matrix that embeds the cumulus cells
• random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate

Structure

belongs to the glycosyl hydrolase 56 family

Compartment

cell membrane, GPI-anchor

Expression

expressed in testis

More general terms

• hyaluronoglucosaminidase; hyaluronidase (HYAL)
• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6677
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6677
• OMIM: https://mirror.omim.org/entry/600930
• UniProt: http://www.uniprot.org/uniprot/P38567.html