cGMP-dependent 3',5'-cyclic phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE (PDE2A)

Function

• cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP & cGMP

nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)

Structure

• homodimer (putative)
• contains 2 GAF domains
• GAF 1 functions as a dimerization domain
• GAF 2 binds cGMP, which activates the enzyme (putative)
• belongs to the cyclic nucleotide phosphodiesterase family, PDE2 subfamily

Compartment

• peripheral membrane

Alternative splicing

• named isoforms=3; PDE2A3, PDE2A1, PDE2A2
• additional isoforms seem to exist

Expression

• expressed in brain > heart, placenta, lung, skeletal muscle, kidney & pancreas

More general terms

• phosphodiesterase 2 (PDE2) or cGMP stimulated phosphodiesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5138
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5138
• OMIM: https://mirror.omim.org/entry/602658
• UniProt: http://www.uniprot.org/uniprot/O00408.html