Rab11 family-interacting protein 5 (Rab11-FIP5, Rab11-interacting protein Rip11, gamma-SNAP-associated factor 1, Gaf-1, phosphoprotein pp75, RAB11FIP5, GAF1, KIAA0857, RIP11)

Function

• Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane
• forms heterooligomeric complex with RAB11FIP4
• binds NAPG & SSA2
• binds RAB11A activated by GTP binding
• binds to vesicles enriched in neutral phospholipids via its C2 domain
• interaction is favored by Mg+2 rather than Ca+2
• phosphorylated on Ser & Thr

Structure

• contains 1 C2 domain

Compartment

• cytoplasm, recycling endosomal membrane, peripheral membrane mitochondrial membrane

Expression

• expressed at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle, pancreas

Pathology

• antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjogren syndrome & in the sera from mothers of children with neonatal lupus erythematosus

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605536
• UniProt: http://www.uniprot.org/uniprot/Q9BXF6.html