voltage-gated K+ channel subunit beta-3; K+ channel subunit beta-3; Kv-beta-3 (KCNAB3, KCNA3B)

Function

• accessory K+ channel protein
• modulates activity of the pore-forming alpha subunit
• alters the functional properties of Kv1.5
• forms heteromultimeric complex with alpha subunits

Structure

• alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (probable)
• belongs to the shaker K+ channel beta subunit family

Compartment

cytoplasm (putative)

Expression

• brain specific
• expressed in cerebellum > cortex, occipital lobe, frontal lobe & temporal lobe
• not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta & skeletal muscle

More general terms

• voltage-gated K+ channel beta subunit
• phosphoprotein

Additional terms

• voltage-gated K+ channel

Database

• UniProt: http://www.uniprot.org/uniprot/O43448.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9196
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9196
• OMIM: https://mirror.omim.org/entry/604111