JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A (JMJD1A, JHDM2A, JMJD1, KDM3A, KIAA0742)

Function

• histone demethylase
• specifically demethylates Lys-9 of histone H3, thus plays a central role in histone code
• preferentially demethylates mono- & dimethylated H3 Lys-9 residue, with a preference for dimethylated residue
  • weak or no activity on trimethylated H3 Lys-9
• demethylation of Lys generates formaldehyde & succinate
• role in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation & transcriptional activation

Cofactor: binds 1 Fe+2 per subunit

Structure

• belongs to the JHDM2 histone demethylase family.
• contains 1 JmjC domain JmjC domain & the C6-type zinc-finger are required for demethylation activity
• Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate association with nuclear receptors

Compartment

nucleus

More general terms

• JmjC domain-containing protein (JMJD)
• dioxygenase
• histone demethylase
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y4C1.html