histone-lysine N-methyltransferase ASH1L (ASH1-like protein, absent small & homeotic disks protein 1 homolog, huASH1, ASH1L, KIAA1420)

Function

• histone methyltransferase
• methylates Lys-4 of histone H3 (putative), a specific tag for epigenetic transcriptional activation

S-adenosyl-L-methionine + histone L-lysine

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S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine

Structure

• belongs to the histone-lysine methyltransferase family, SET2 subfamily
• contains 3 A.T hook DNA-binding domains
• contains 1 AWS domain
• contains 1 BAH domain
• contains 1 bromo domain
• contains 1 PHD-type zinc finger
• contains 1 post-SET domain
• contains 1 SET domain

Compartment

• nucleus, cell junction, tight junction
• relevance of tight junction localization unclear

Expression

• widely expressed
• highest level in brain, heart, kidney

More general terms

• histone N-methyltransferase
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/607999
• UniProt: http://www.uniprot.org/uniprot/Q9NR48.html