replication initiator 1 (zinc finger protein 464, DHFR oribeta-binding protein RIP60, 60 kD replication initiation region protein, 60 kD origin-specific DNA-binding protein, ATT-binding protein, REPIN1, RIP60, ZNF464)

Function

• sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication
• binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) & a 2nd, homologous ATT sequence of opposite orientation situated within the OBR zone
• facilitates DNA bending near origins of replication
• found in a complex with RIP60 & RIP100

Structure

• homodimers & homomultimers
• contains 15 C2H2-type zinc fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• zinc finger protein
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BWE0.html