Rab effector Noc2; rabphilin-3A-like protein; No C2 domains protein (RPH3AL, NOC2)

Function

• Rab GTPase effector
• role in late steps of regulated exocytosis, both in endocrine & exocrine cells
• RAB3B effector protein in epithelial cells (putative)
• recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells via N-terminus of RabBD domain
• interacts with RAB3A, RAB3B, RAB3C & RAB3D
• interacts with ZYX

Structure

• contains 1 FYVE-type zinc finger.
• contains 1 RabBD domain (Rab-binding domain)

Compartment

• cytoplasm, cytoplasmic vesicle, secretory vesicle membrane
• recruited to vesicle membrane (GTP- & RAB3B-dependent in epithelial cells)

Alternative splicing

named isoforms=2

Expression

• expressed in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney, liver
• detected in epithelial cells

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/604881
• UniProt: http://www.uniprot.org/uniprot/Q9UNE2.html