F-box only protein-40 (muscle disease-related protein, FBXO40, FBX40, KIAA1195)
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Function
- substrate-recognition component of the SCF complex
- interacts with SKP1A & CUL1
Structure
- contains 1 F-box domain
- contains 1 TRAF-type zinc finger
Genetics
- SNP in STXBP5L gene & haplotype linkage with another SNP that increases expression of FBXO40 is associated with less photoaging of facial skin[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UH90.html
- ↑ 2.0 2.1 Le Clerc S et al. A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging. J Invest Dermatol 2013 Apr; 133:929. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2322314