zinc finger protein 307; zinc finger protein with KRAB & SCAN domains 4; P373c6.1; zinc finger protein 427 (ZKSCAN4, ZNF307, ZNF427)

Function

• may be involved in the transcriptional activation of MDM2 & EP300 genes
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 7 C2H2-type Zn+2 fingers
• contains 1 KRAB domain
• contains 1 SCAN box domain

Compartment

nucleus

Expression

• expressed in adult heart, brain, placenta, lung & kidney, but not in adult liver & skeletal muscle
• in 17-day old embryo, detected in liver, skeletal muscle, brain, heart & small intestine

More general terms

• C2H2 type zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=387032
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:387032
• OMIM: https://mirror.omim.org/entry/611643
• UniProt: http://www.uniprot.org/uniprot/Q969J2.html