ubiquitin carboxyl-terminal hydrolase 45; deubiquitinating enzyme 45; ubiquitin thiolesterase 45; ubiquitin-specific-processing protease 45 (USP45)

Function

• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

• belongs to the peptidase C19 family
• contains 1 UBP-type Zn+2 finger

Alternative splicing

• named isoforms=3
• some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• broadly expressed
• with highest levels in ovary, skeletal muscle & spleen

More general terms

• ubiquitin C-terminal hydrolase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85015
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85015
• UniProt: http://www.uniprot.org/uniprot/Q70EL2.html