diacylglycerol kinase eta; diglyceride kinase eta; DGK-eta; DAG kinase eta (DGKH)

Function

• phosphorylates diacylglycerol to generate phosphatidic acid
• phosphorylation does not inhibit catalytic activity

ATP + 1,2-diacylglycerol
      <-->
ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• isoform 1 forms homooligomers through the SAM domain also able to form heterooligomers with SAM domain-containing isoforms of DGKD oligomerization of isoform 1 inhibits its catalytic activity
• belongs to the eukaryotic diacylglycerol kinase family
• contains 1 DAGKc domain
  • contains 1 PH domain
  • contains 2 phorbol-ester/DAG-type zinc fingers
  • contains 1 SAM domain (sterile alpha motif)

Compartment

• cytoplasm
• translocated from t cytoplasm to endosomes in response to stress stimuli
• isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli
• isoform 1 exhibits sustained endosomal association

Alternative splicing

named isoforms=4

Expression

• isoform 2 is ubiquitously expressed
• isoform 1 is expressed only in testis, kidney, colon

More general terms

• diacylglycerol kinase
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/604071
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=160851
• UniProt: http://www.uniprot.org/uniprot/Q86XP1.html