diacylglycerol kinase delta; DAG kinase delta; 130 kD diacylglycerol kinase; diglyceride kinase delta; DGK-delta (DGKD, KIAA0145)

Function

• may function as signaling molecule
• isoform 2 may be involved in cell growth & tumorigenesis
• involved in clathrin-dependent endocytosis
• isoform 1 H domain is phosphorylated
• the two isoforms are able to form homo- & hetero- oligomer structures (at least tetramers)
• isoform 2 interacts with AP2A2

Inhibition:

• partially inhibited by phosphatidylserine

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• belongs to the eukaryotic diacylglycerol kinase family
• contains 1 DAGKc domain
• contains 1 PH domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers
• contains 1 SAM (sterile alpha motif) domain

Compartment

• isoform 2: cytoplasm
• isoform 1: membrane, peripheral membrane

Alternative splicing

named isoforms=2

Expression

• isoform 2 is ubiquitously expressed including in tumor tissues
• isoform 1 is expressed in ovary, spleen & some tumor-derived cells

More general terms

• diacylglycerol kinase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8527
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8527
• OMIM: https://mirror.omim.org/entry/601826
• UniProt: http://www.uniprot.org/uniprot/Q16760.html