apolipoprotein F; apo-F; lipid transfer inhibitor protein; LTIP (APOF)

Function

• minor apolipoprotein that associates with LDL
• inhibits cholesteryl ester transfer protein (CETP) activity & appears to regulate cholesterol transport
• associates, to a lesser degree, with VLDL, apo A1 & apo A2

Structure

• O-glycosylated with core 1 or possibly core 8 glycans

Compartment

secreted

Expression

• expressed by the liver & secreted into plasma

Notes

• uncertain whether Met-1 or Met-12 is the initiator

More general terms

• apolipoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=319
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:319
• OMIM: https://mirror.omim.org/entry/107760
• UniProt: http://www.uniprot.org/uniprot/Q13790.html