zinc finger protein SNAI2; protein snail homolog 2; neural crest transcription factor Slug (SNAI2, SLUG, SLUGH)

Function

• transcriptional repressor
• role in generation & migration of neural crest cells

Structure

• belongs to the snail C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Expression

• expressed in placenta & adult heart, pancreas, liver, kidney & skeletal muscle

Pathology

• defects in SNAI2 are a cause of neural tube defects
• defects in SNAI2 are the cause of Waardenburg syndrome type 2D

More general terms

• snail protein homolog
• C2H2 type zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6591
• OMIM: https://mirror.omim.org/entry/602150
• OMIM: https://mirror.omim.org/entry/608890
• UniProt: http://www.uniprot.org/uniprot/O43623.html