transcriptional adapter 2-like; ADA2-like protein (TADA2L, TADA2A)

Function

• binds double-stranded DNA
• binds dinucleosomes at the linker region between neighboring nucleosomes (putative)
• chromatin remodeling (putative)
• function of some acidic activation domains, which activate transcription from a distant site
• interacts with GCN5 & NR3C1
• associated with the P/CAF protein in the PCAF complex
• component of the PCAF complex
  • associated with the P/CAF protein in the PCAF complex

Structure

• contains 1 SANT domain
• contains 1 SWIRM domain

Compartment

nucleus

Expression

• expressed in all tissues
• most abundant in testis

More general terms

• DNA-binding protein

Component of

• PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex

Database

• OMIM: https://mirror.omim.org/entry/602276
• UniProt: http://www.uniprot.org/uniprot/O75478.html