nucleobindin-1; CALNUC (NUCB1, NUC)

Function

• major Ca+2-binding protein of the Golgi
• may have a role in Ca+2 homeostasis (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with GNAI2 & GNAI3

Structure

• the EF-hand domains are unfolded in the absence of Ca+2 & fold upon Ca+2 addition
• belongs to the nucleobindin family
• contains 2 EF-hand domains

Compartment

• Golgi, cis-Golgi network membrane
• peripheral membrane protein; lumenal side (putative)
• cytoplasm (putative)
• small fraction of the protein may be cytoplasmic

Expression

• expressed both in fetal & adult heart, lung, liver, kidney & brain, & in adult skeletal muscle, placenta & pancreas

Notes

• discovered as DNA-binding protein in the serum of lupus-prone mice

More general terms

• DNA-binding protein
• Ca+2 binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q02818.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4924
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4924
• OMIM: https://mirror.omim.org/entry/601323