neuroendocrine protein 7B2; pituitary polypeptide; secretogranin V; secretogranin-5; secretory granule endocrine protein I; contains: N-terminal peptide; C-terminal peptide (SCG5, SGNE1)

Function

• acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway
• binds to inactive PCSK2 in the endoplasmic reticulum & facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured & activated
• also required for cleavage of PCSK2 but does not appear to be involved in its folding
• role in regulating pituitary hormone secretion
• the C-terminal peptide inhibits PCSK2 in vitro
• proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides (putative)
• sulfated on Tyr (putative)
• interacts with PCSK2/PC2 early in the secretory pathway
• dissociation occurs at later stages

Structure

belongs to the 7B2 family

Compartment

• secreted
• neuroendocrine & endocrine secretory granules

Alternative splicing

named isoforms=2

More general terms

• chromogranin; secretogranin;granin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6447
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6447
• OMIM: https://mirror.omim.org/entry/173120
• UniProt: http://www.uniprot.org/uniprot/P05408.html