A disintegrin & metalloproteinase with thrombospondin type 1 motif 20; ADAMTS-20; ADAM-TS 20; ADAM-TS20 (ADAMTS20)

Function

• may play a role in tissue-remodeling process occurring in both normal & pathological conditions
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• contains 1 disintegrin domain
• contains 1 GON domain
• contains 1 peptidase M12B domain
• contains 15 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Alternative splicing

named isoforms=2

Expression

• expressed at low levels in testis, prostate, ovary, heart, placenta, lung & pancreas

Pathology

• overexpressed in several carcinomas:
  • brain neoplasms
  • colon carcinoma
  • breast carcinoma

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80070
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80070
• OMIM: https://mirror.omim.org/entry/611681
• UniProt: http://www.uniprot.org/uniprot/P59510.html