A disintegrin & metalloproteinase with thrombospondin type 1 motif 5; ADAMTS-5; ADAM-TS 5; ADAM-TS5; aggrecanase-2; ADMP-2; A disintegrin & metalloproteinase with thrombospondin motifs 11; ADAMTS-11; ADAM-TS 11 (ADAMTS5, ADAMTS11, ADMP2)

Function

• cleaves aggrecan, a cartilage proteoglycan, & may be involved in its turnover
• may play an important role in destruction of aggrecan in arthritic diseases
• may play a role in proteolytic processing mostly during the peri-implantation period
• precursor is cleaved by a furin endopeptidase
• cleaves aggrecan at the 392-Glu-|-Ala-393 site

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• the spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon the activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 2 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• expressed at low level in placenta primarily but also detected in heart & brain, cervix, uterus, bladder, esophagus, rib cartilage, fibrous tissue

Pathology

• expressed in chondroblastoma
• detected in a joint capsule from a patient with osteoarthritis

More general terms

• ADAMTS protease
• glycoprotein

Additional terms

• aggrecan core protein; cartilage-specific proteoglycan core protein; CSPCP; chondroitin sulfate proteoglycan core protein 1; contains: aggrecan core protein 2 (ACAN, AGC1, CSPG1, MSK16)
• cartilage
• osteoarthritis (OA)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11096
• OMIM: https://mirror.omim.org/entry/605007
• UniProt: http://www.uniprot.org/uniprot/Q9UNA0.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11096