phosphatase-2A regulatory subunit B' delta (PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D)

Function

• B regulatory subunit might modulate substrate selectivity & catalytic activity, & also might direct the localization of the catalytic enzyme to a particular subcellular compartment
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the phosphatase 2A regulatory subunit B56 family

Compartment

• cytoplasm. nucleus
• nuclear in interphase, nuclear during mitosis

Alternative splicing

named isoforms=3

Expression

• isoform delta-2 is widely expressed
• isoform delta-1 is highly expressed in brain
• induced by retinoic acid in neuroblastoma cell lines

More general terms

• phosphatase-2A B subunit

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5528
• OMIM: https://mirror.omim.org/entry/601646
• UniProt: http://www.uniprot.org/uniprot/Q14738.html