fraction of exhaled nitric oxide (FeNo)

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Indications

* FeNo levels > 50 ppb correlate with eosinophil-associated airway inflammation & predict response to inhaled glucocorticoids[3]

* FeNo levels < 25 ppb make eosinophil-associated airway inflammation & response to inhaled glucocorticoids less likely[3]

Contraindications

  • not for determining treatment of asthma in the general population[3]

Clinical significance

Exhaled nitric oxide reflects:

Increases

More general terms

References

  1. Smith AD et al, Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 352:2163, 2005 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15914548
  2. Wang Z, Pianosi P, Keogh K et al Agency for Healthcare Research and Quality (AHRQ) The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management. Comparative Effectiveness Review No. 197. Dec 20, 2017 https://www.effectivehealthcare.ahrq.gov/topics/asthma-nitric-oxide/research
  3. 3.0 3.1 3.2 3.3 3.4 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022