fraction of exhaled nitric oxide (FeNo)
Jump to navigation
Jump to search
Indications
- aid in the diagnosis of asthma [NGC, NICE]
- evaluation of non-asthmatic eosinophilic bronchitis
- aid in the prediction of response to inhaled glucocorticoids*[3]
* FeNo levels > 50 ppb correlate with eosinophil-associated airway inflammation & predict response to inhaled glucocorticoids[3]
* FeNo levels < 25 ppb make eosinophil-associated airway inflammation & response to inhaled glucocorticoids less likely[3]
Contraindications
Clinical significance
Exhaled nitric oxide reflects:
- bronchial wall inflammation
- airway hyperresponsiveness
- induced sputum eosinophilia
Increases
- asthma inadequately controlled
- non-asthmatic eosinophilic bronchitis
More general terms
References
- ↑ Smith AD et al, Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 352:2163, 2005 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15914548
- ↑ Wang Z, Pianosi P, Keogh K et al Agency for Healthcare Research and Quality (AHRQ) The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management. Comparative Effectiveness Review No. 197. Dec 20, 2017 https://www.effectivehealthcare.ahrq.gov/topics/asthma-nitric-oxide/research
- ↑ 3.0 3.1 3.2 3.3 3.4 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022