eosinophilic bronchitis
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Etiology
Pathology
- eosinophilic infiltration of the bronchial mucosa
Clinical manifestations
- dry, non-productive chronic cough
Laboratory
- complete blood count: eosinophil count may be normal[3]
- sputum eosinophils &/or fraction of exhaled nitric oxide
Diagnostic procedures
- pulmonary function tests normal
- methacholine challenge test normal
- bronchoscopy with bronchial mucosal biopsy required for definitive diagnosis
- diffuse nodules in the tracheobronchial mucosa[3] (see image)
Radiology
- chest X-ray normal
Differential diagnosis
Management
- therapeutic trial of inhaled glucocorticoids prior to extensive workup
- systemic glucorticoids for 1 month (case report) in addition to inhaled glucocorticoids after diagnosis by bronchoscopy with bronchial mucosal biopsy[3]
- continue inhaled glucocorticoid for an additonal 2 months (case report)[3]
- prognosis: no recurrence at 6 months (case report)[3]
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16, 19. American College of Physicians, Philadelphia 2012, 2021
- ↑ Desai D, Brightling C. Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. Otolaryngol Clin North Am. 2010 Feb;43(1):123-30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20172262
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Ren Y, Dai H. Images in Clinical Medicine: Eosinophilic Bronchitis. N Engl J Med 2017; 377:873. August 31, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28854083 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1616156