DGCR6 protein; DiGeorge syndrome critical region 6 (DGCR6)

Function

• may play a role in neural crest cell migration into pharyngeal pouch 3 & 4

Structure

belongs to the gonadal family

Compartment

nucleus; predominantly nuclear

Expression

• found in all tissues examined
• highest expression in liver, heart & skeletal muscle
• lower expression in pancreas & placenta
• weak expression in brain
• increased levels in several tumor cell lines, including adenocarcinoma of the lung & colon adenocarcinoma & breast carcinoma
• strongly induced in Burkitt's lymphoma & lymphocytes transformed by EBV

More general terms

• DiGeorge syndrome critical region protein (DGCR)

Additional terms

• DiGeorge syndrome; velocardiofacial syndrome; pharyngeal pouch syndrome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8214
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8214
• OMIM: https://mirror.omim.org/entry/601279
• UniProt: http://www.uniprot.org/uniprot/Q14129.html