phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Down syndrome critical region protein 5; Down syndrome critical region protein C; phosphatidylinositol-glycan biosynthesis class P protein; PIG-P (PIGP, DCRC, DSCR5, DSCRC, NPD010)

Function

• part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis
• glycolipid biosynthesis; GPI-anchor biosynthesis
• associates with PIGA, PIGC, PIGH, PIGQ & DPM2

Structure

belongs to the PIGP family

Compartment

membrane (potential)

Alternative splicing

named isoforms=3; A,B,C

Expression

ubiquitous

More general terms

• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
• Down syndrome critical region protein
• transmembrane 2 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51227
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51227
• OMIM: https://mirror.omim.org/entry/605938
• UniProt: http://www.uniprot.org/uniprot/P57054.html