phosphatidylinositol N-acetylglucosaminyltransferase subunit C; phosphatidylinositol-glycan biosynthesis class C protein; PIG-C (PIGC, GPI2)

Function

• part of the complex catalyzing transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the 1st step of GPI biosynthesis
• glycolipid biosynthesis; GPI-anchor biosynthesis
• associates with PIGA, PIGH, PIGP, PIGQ & DPM2
• the latter is not essential for activity

Structure

belongs to the PIGC family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

More general terms

• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
• transmembrane 4 protein

Additional terms

• phosphatidylinositol [PI] glycan

Component of

• UDP-N-acetylglucosamine phosphatidylinositol transferase (GPI-GlcNAc transferase, GPI-GnT)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5279
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5279
• OMIM: https://mirror.omim.org/entry/601730
• UniProt: http://www.uniprot.org/uniprot/Q92535.html