proto-oncogene FRAT1; Frequently rearranged in advanced T-cell lymphomas 1; FRAT-1 (FRAT1)

Function

• positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3
• may play a role in tumor progression & collaborate with PIM1 & MYC in lymphomagenesis
• phosphorylated (putative)
• binds DVL1
• binds GSK-3 & prevents GSK-3-dependent phosphorylation

Structure

• belongs to the GSK-3-binding protein family

Compartment

cytoplasm

More general terms

• GSK-3 binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10023
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10023
• OMIM: https://mirror.omim.org/entry/602503
• UniProt: http://www.uniprot.org/uniprot/Q92837.html