kelch domain-containing protein 2; hepatocellular carcinoma-associated antigen 33; host cell factor homolog LCP; host cell factor-like protein 1; HCLP-1 (KLHDC2, HCA33)

Function

• represses CREB3-mediated transcription by interfering with CREB3-DNA binding
• directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA & herpes simplex virus transactivator VP16

Structure

contains 6 kelch repeats

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• high expression in skeletal muscle, heart, pancreas & liver
• undetectable in peripheral blood leukocytes

More general terms

• kelch domain containing protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23588
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23588
• OMIM: https://mirror.omim.org/entry/611280
• UniProt: http://www.uniprot.org/uniprot/Q9Y2U9.html