synaptosomal-associated protein 29; SNAP-29; vesicle-membrane fusion protein SNAP-29; soluble 29 kD NSF attachment protein (SNAP29)

Function

• role in multiple membrane trafficking steps
• binds tightly to multiple syntaxins

Structure

• belongs to the SNAP-25 family
• contains 1 t-SNARE coiled-coil homology domain

Compartment

• cytoplasm, membrane; peripheral membrane protein
• cell junction, synapse, synaptosome.
• appears to be mostly membrane-bound, probably via interaction with syntaxins
• a significant portion is cytoplasmic

Expression

• found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen & pancreas

Pathology

• defects in SNAP29 are the cause of CEDNIK syndrome

More general terms

• synaptosomal-associated protein (SNAP)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9342
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9342
• OMIM: https://mirror.omim.org/entry/604202
• OMIM: https://mirror.omim.org/entry/609528
• UniProt: http://www.uniprot.org/uniprot/O95721.html