Ras association domain-containing protein 4 (RASSF4)

Function

• potential tumor suppressor
• may act as a KRAS effector protein
• may promote apoptosis & cell cycle arrest
• interacts directly with activated KRAS (GTP-dependent)

Structure

• contains 1 Ras-associating domain
• contains 1 SARAH domain

Alternative splicing

named isoforms=4

Expression

• widely expressed
• frequently down-regulated in tumor cell lines

More general terms

• Ras association domain-containing protein (RASSF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H2L5.html