Ras association domain-containing protein 2 (RASSF2, KIAA0168)

Function

• tumor suppressor (putative)
• role as KRAS-specific effector protein
• may promote apoptosis & cell cycle arrest
• interacts directly with activated KRAS (GTP-dependent)

Structure

• contains 1 Ras-associating domain
• contains 1 SARAH domain

Compartment

nucleus

Expression

• widely expressed
• highest levels in brain, placenta, peripheral blood & lung

Pathology

• frequently down-regulated in lung tumor cell lines

More general terms

• Ras association domain-containing protein (RASSF)

Database

• UniProt: http://www.uniprot.org/uniprot/P50749.html