regulator of G-protein signaling 17 (RGS17)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
• binds selectively to Gz-alpha & Gi-alpha-2 subunits, accelerates their GTPase activity & regulates their signaling activities
• Gz-alpha activity is inhibited by phosphorylation & palmitoylation of the G-protein
• negatively regulates mu-opioid receptor-mediated activation of G-proteins (putative)
• fatty acylated
• heavily palmitoylated in the cysteine string motif (putative)
• N- & O-glycosylated in synapsomal membranes
• Ser phosphorylated in synapsomal membranes
• sumoylated by SUMO1 & SUM02 in synaptosomes
• sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G-alpha subunits (putative)

Structure

contains 1 RGS domain

Compartment

• membrane, lipid-anchor
• nucleus, cytoplasm
• shuttles between the cytoplasm/cell membrane & the nucleus
• anchored to the membrane through palmitoylation (putative)

Expression

• predominantly expressed in the cerebellum
• also expressed in the cortex & medulla
• weakly expressed in a number of peripheral tissues notably spleen, lung & leukocytes

More general terms

• regulator of G-protein signaling
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26575
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26575
• OMIM: https://mirror.omim.org/entry/607191
• UniProt: http://www.uniprot.org/uniprot/Q9UGC6.html