regulator of G-protein signaling 11 (RGS11)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
• heterodimer with Gbeta5
• interacts with RGS7BP, regulating subcellular location of the RGS11/Gbeta5 heterodimer (putative)

Structure

• contains 1 DEP domain
• contains 1 G protein gamma domain
• contains 1 RGS domain

Alternative splicing

named isoforms=2

More general terms

• regulator of G-protein signaling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8786
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8786
• OMIM: https://mirror.omim.org/entry/603895
• UniProt: http://www.uniprot.org/uniprot/O94810.html