coiled-coil domain-containing protein 5; enhancer of invasion-cluster; HEI-C (CCDC5, HEIC, HAUS1)

Function

• regulates spindle function & integrity during metaphase- anaphase transition
• associates with microtubules
• interaction with microtubules is strong during mitosis, & weak or absent during interphase

Compartment

• cytoplasm
• localizes with spindle poles in mitotic cells
• in metaphase, localizes to mitotic asters & is punctate on the microtubule array
• during later stages of mitosis, it remains on the spindle but is not present at the interzone, & finally is observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody
• does not colocalize with tubulin cytoskeleton in interphase

Alternative splicing

named isoforms=2

Expression

• widely expressed, including pancreas, kidney, skeletal muscle, liver, heart > lung, brain, placenta
• CCDC5 protein levels remain constant through the cell cycle

Pathology

• CCDC5-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle phase & induces apoptosis

More general terms

• coiled-coil domain-containing protein (CCDC)

Database

• OMIM: https://mirror.omim.org/entry/608775
• UniProt: http://www.uniprot.org/uniprot/Q96CS2.html