testis-specific Y-encoded protein 1; cancer/testis antigen 78; CT78 (TSPY1, TSPY)

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Function

Structure

Compartment

Alternative splicing

named isoforms=2 additional isoforms seem to exist

Expression

Pathology

Polymorphism

  • variants Val-Glu-Val-Val-Ala-Glu-79 ins & Arg-195 are shown to be present in a number of TSPY1 copies of the Yp11 loci
  • variant Arg-195 is shown to be present at least in one TSPY1 copy of the Yq locus
  • maps to a tandemly repeated region on chromosome Yp11;
  • at least one copy is reported originating from Yq
  • the gene is thought to be present with an inter-individual variation in copy number & between 20 & 60 copies per Y chromosome are expected
  • 35 tandemly repeated gene copies on Yp11 originating from one individual[2]

More general terms

More specific terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q01534.html
  2. 2.0 2.1 Skaletsky H The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003 Jun 19;423(6942):825-37. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12815422

Database