suppressor of cytokine signaling 6; SOCS-6; cytokine-inducible SH2 protein 4; CIS-4 (SOCS6, CIS4)

Function

• may be a substrate recognition component of a SCF-like ECS (elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins (putative)
• protein modification; protein ubiquitination
• interacts with RBCK1
• interacts with phosphorylated IRS4

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
• contains 1 SH2 domain
• contains 1 SOCS box domain

More general terms

• suppressor of cytokine signaling family (SOCS family protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9306
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9306
• OMIM: https://mirror.omim.org/entry/605118
• UniProt: http://www.uniprot.org/uniprot/O14544.html