tubby-related protein 3; tubby-like protein 3 (TULP3, TUBL3)

Function

• negatively regulates SHH signal transduction
• probably functions in signal transduction from heterotrimeric G protein-coupled receptors
• binds to phosphorylated inositide lipids

Structure

belongs to the TUB family

Compartment

• nucleus, cell membrane, cell projection, cilium (putative)
• cytoplasm, secreted
• does not have a cleavable signal peptide & is secreted by a non-conventional pathway (putative)
• translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein Gq-alpha

Expression

• ovary
• testis
• thyroid
• spinal cord

More general terms

• tub family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7289
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7289
• OMIM: https://mirror.omim.org/entry/604730
• UniProt: http://www.uniprot.org/uniprot/O75386.html