RUN domain-containing protein 3B (rap2-binding protein 9, rap2-interacting protein 9, RUNDC3B, RPIB9, RPIP9)

Introduction

interacts with RAP2A (putative)

Structure

• belongs to the RUNDC3 family
• contains 1 RUN domain

Alternative splicing

named isoforms=4

Expression

• isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine & prostate
• isoform 1 is expressed in the brain, testis & adrenal gland

Pathology

• activated in tumorigenic breast cancer cell lines & in the primary tumor of breast cancer patients
• activation correlates with metastatic lymph node invasion & can be detected in metastatic epithelial cells from the lymph nodes & in the bone marrow of patients

More general terms

• RUN domain-containing protein (RUNDC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1546
• UniProt: http://www.uniprot.org/uniprot/Q96NL0.html