FYVE, RhoGEF & PH domain-containing protein 2 (zinc finger FYVE domain-containing protein 4, FGD2, ZFYVE4)

Function

• may activate CDC42 by exchanging bound GDP for free GTP
• role in regulating the actin cytoskeleton & cell shape

Structure

• contains 1 DH domain (DBL-homology domain)
• contains 1 FYVE-type zinc finger
• contains 2 PH domains

Compartment

cytoplasm

Alternative splicing

named isoforms=5

More general terms

• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• OMIM: https://mirror.omim.org/entry/605091
• UniProt: http://www.uniprot.org/uniprot/Q7Z6J4.html