FYVE, RhoGEF & PH domain-containing protein 3 (zinc finger FYVE domain-containing protein 5, FGD3, ZFYVE5)

Function

• promotes the formation of filopodia
• may activate CDC42 via exchanging bound GDP for free GTP
• role in regulating actin cytoskeleton & cell shape

Structure

• contains 1 DH domain (DBL-homology domain)
• contains 1 FYVE-type zinc finger
• contains 2 PH domains

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• UniProt: http://www.uniprot.org/uniprot/Q5JSP0.html