neuropeptide W; preproprotein L8; hPPL8; G protein-coupled receptor ligand 8; contains: neuropeptide W-23; NPW23; hL8; neuropeptide W-30; NPW30; hL8C (NPW, PPL8, PPNPW)

Function

• 2 neuropeptides, neuropeptide W-23 & neuropeptide W-30 derived from a common precursor
• role in regulation of neuroendocrine signaling in the anterior pituitary gland
• stimulates water & food intake
• may play a role in hypothalamic response to stress
• activates GPR7 & GPR8

Structure

• two peptides of 23 & 30 amino acids, NPW23 & NPW30; NPW23 activates GPR7 & GPR8 more efficiently than NPW30

Compartment

secreted

Expression

• high levels
  • substantia nigra, fetal kidney, trachea
• lower levels
  • testis, uterus, ovary placenta
• not detectable in many regions of the CNS

Pathology

• detected at high levels in lymphoblastic leukemia & colorectal adenocarcinoma

More general terms

• neuropeptide

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283869
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:283869
• OMIM: https://mirror.omim.org/entry/607997
• UniProt: http://www.uniprot.org/uniprot/Q8N729.html