neuropeptides B/W receptor type 1; G-protein coupled receptor 7 (NPBWR1, GPR7)

Function

• interacts specifically with a number of opioid ligands
• receptor for neuropeptides B & W, which may be involved in neuroendocrine system regulation, food intake & the organization of other signals
• higher affinity for neuropeptide B

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

• found in cerebellum & frontal cortex
• expressed in hipppocampus, amygdala & trachea > fetal brain, pituitary gland & prostate
• not expressed in caudate, accumbens, kidney or liver

Pathology

detected at high levels in lung carcinoma

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600730
• UniProt: http://www.uniprot.org/uniprot/P48145.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2831